Having more white space around the article and the Ad will definitely increase your click through rate. In my case, this is one of the real secrets behind the high click through rate in my Adsense ads. Your objective should be to get the reader’s attention to the Adsense ad and the article. Therefore, it is important to have other areas blank as much as possible to centre reader’s attention to the Ad and the article. Remove all unnecessary items which are cluttered around the article and the Ad and have more white space on either side of the page.