So your guy acts like a Neandertal?

In today's issue of Science, 18 May 2007, Elizabeth Pennisi's article entitled
No Sex Please, We're Neandertals gets directly to the issue of "sexual relationships."

The question: "Did Neandertals and modern humans interbreed?

Last year, writes Pennisi, that simple question took on new life when two groups of researchers reported the first results from sequencing parts of a Neandertal's nuclear genome. The answer, however, was equivocal: One group reported no evidence of interbreeding; the other reported tantalizing hints of mating (Science, 17 November 2006, p. 1068)

http://www.sciencemag.org/cgi/content/full/314/5802/1068

That was then, But this is NOW!

According to Pennisi, "A paper presented last week at the "Biology of Genomes" meeting, in Cold Springs Harbor, New York, gives the evidence a strong shove in the direction of the "no-sex" camp.

Pennisi reports, "The new findings also push back the date that Neandertals split from the human branch of the primate tree by 200,000 years--to 800,000 years ago. And another study shows that this ancient human ranged 2000 kilometers farther east--into southern Siberia--something anthropologists have suspected but not confirmed.

"These findings," writes Pennisi, "come out of an ongoing effort by Svante Pääbo of the Max Planck Institute for Evolut ionary Anthropology in Leipzig, Germany, to sequence the Neandertal genome. Until last year, researchers had only been able to extract and decipher mitochondrial DNA from Neandertal fossils."

"But in 2006, Pennisis says, "Pääbo and, using a different approach, James Noonan of Lawrence Berkeley National Laboratory in California and Edward Rubin, director of the Department of Energy Joint Genome Institute in Walnut Creek, California, sequenced nuclear DNA from a Neandertal bone from Croatia."

Pennisi reports, "Rubin and Noonan found no support for interbreeding in 65,000 bases their group sequenced, a finding in line with conclusions from mitochondrial DNA studies. Pääbo, however, found enough so-called singlenucleotide polymorphisms (SNPs) shared with humans, but not chimps, among the million bases his group sequenced to question that conclusion."

"In that study, Pääbo used preexisting databases of human variation." States Pennisi. "Because those databases focus on common SNPs, Pääbo worried that biases might skew the analysis. So David Reich of Harvard Medical School in Boston and James Mullikin of the National Human Genome Research Institute in Bethesda, Maryland, have now compared SNPs in new Neandertal sequences to random SNPs obtained from one African and from one European. The result: "There's no indication of gene flow," Pääbo reported. Pääbo and his group got the same result when they examined variation in the Y chromosome, looking for signs of Homo sapiens DNA embedded in the Neandertal sequence."

Science writer Pennisi quotes James Noonan and points out, it may never be possible to prove beyond doubt that interbreeding did not occur. "But if I were to make a guess, I would say more sequence will just confirm [these results]," Noonan says. "It convinces me."

"Last year", writes Pennisi, "based on comparisons with the human and chimp genomes, Pääbo's group estimated that Neandertals split off from the human lineage about 600,000 years ago. But they have since found that that estimate changes by 400,000 years depending on the order in which they match up each species' sequence. A new three-way comparison that doesn't give one pairing priority over another comes out at 800,000 years, Pääbo and his Max Planck Institute colleague Richard Green reported at the meeting."

"In a side project, Pääbo and his graduate student Johannes Krause have examined 30,000- to 38,000-year-old human fossils from Uzbekistan and the Atlai region of southern Siberia whose identities were a mystery." Pennisi Reports, "When the researchers compared the bones' mitochondrial DNA with that from more than a half-dozen Neandertals, they found that the Asian fossils were clearly Neandertal." Pääbo says, "It tells us that Neandertals were much more widespread than we thought."

Pennisi observes, "Neandertals may have roamed far and wide, but when it came to sex, they apparently stuck to their own."

And now you see! If "he," Your Guy, is a Neandertal, you and he are made for eachother!

Likely, he will be a faithful fellow and not attracted to all those cro-magnon babes, that might seem tempting to some. It appears these guys didn't mess around. Of course, it takes two!

www.archaeology.org/9609/newsbriefs/neandertals.html

www.archaeology.org/9609/newsbriefs/neandertals.html